Maeda, N., Ohmoto, M., Yamamoto, K., Kurokawa, A., Narukawa, M., Ishimaru, Y., Misaka, T., Matsumoto, I., and Abe, K.*
Expression of serotonin receptor genes in cranial ganglia.
Neurosci. Lett., 617, 46-51, 2016.
[PubMed]

Yoshimoto, J., Okada, S., Kishi, M., and Misaka, T.*
Ulex europaeus agglutinin-1 is a reliable taste bud marker for in situ hybridization analyses.
J. Histochem. Cytochem., 64, 205-215, 2016.
[PubMed]

Ishimaru, Y.*, Kozuka, C.*, Nakajima, K.*, and Sasaki, T.* (Review)
Expanding frontiers in weight-control research explored by young investigators.
J. Physiol Sci., 67, 83-95, 2016.
[PubMed]

Tsutsui, K., Otoh, M., Sakurai, K., Suzuki-Hashido, N., Hayakawa, T., Misaka, T., Ishimaru, Y., Aureli, F., Melin, A.D., Kawamura, S.*, and Imai, H.*
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys.
BMC Evol. Biol., 16, 208, 2016.
[PubMed]

Imai, H.*, Suzuki-Hashido, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Ishiguro, M., Masuda, K., Abe, K., Misaka, T., and Hirai, H.
Amino acid residues of bitter taste receptor TAS2R16 that determine sensitivity in primates to beta-glycosides.
Biophys. Physicobiol., 13, 165-171, 2016.
[Article]

Ushiama, S.^#, Ishimaru, Y.^#*, Narukawa, M.^#, Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H., and Abe K.*
Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1-deficient mice.
EBioMedicine, 8, 60-71, 2016.
[PubMed]

Nakajima, K.^#, Cui, Z.^# , Li, C., Meister, J., Cui, Y., Fu, O., Smith, A.S., Jain, S., Lowell, B.B., Krashes, M.J., and Wess, J.*
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.
Nat. Commun., 7, 10268, 2016.
[PubMed] ［研究紹介］

Koizumi, T., Terada, T.*, Nakajima, K., Kojima, M., Koshiba, S., Matsumura, Y., Kaneda, K., Asakura, T., Shimizu-Ibuka, A., Abe, K., and Misaka, T.*
Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor.
Sci. Rep., 5, 12947, 2015.
[PubMed]

Kurokawa, A.^#, Narukawa, M.^#, Ohmoto, M., Yoshimoto, J., Abe, K., and Misaka, T.*
Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction.
J. Neurochem., 133, 806-814, 2015.
[PubMed] ［研究紹介］

Suzuki-Hashido, N., Hayakawa, T., Matsui, A., Go, Y., Ishimaru, Y., Misaka, T., Abe, K., Hirai, H., Satta, Y., and Imai H.*
Rapid expansion of phenylthiocarbamide non-tasters among Japanese macaques.
PLoS ONE, 10, e0132016, 2015.
[PubMed]

Shim, J. ^#, Son, H.J.^#, Kim, Y., Kim, K.H., Kim, J.T., Moon, H., Kim, M.J., Misaka, T., and Rhyu, M.R.*
Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2.
PLoS ONE, 10, e0124030, 2015.
[PubMed]

Kim, M.J., Son, H.J., Kim, Y., Misaka, T., and Rhyu, M.R.*
Umami-bitter interactions: the suppression of bitterness by umami peptides via human bitter taste receptor.
Biochem. Biophys. Res. Commun., 456, 586-590, 2015.
[PubMed]

Baldwin, M.W.^#,*, Toda, Y.^#, Nakagita, T., O'Connell, M.J., Klasing, K.C., Misaka, T., Edwards, S.V., Liberles, S.D.*
Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor.
Science, 345, 929-933, 2014.
[PubMed] ［研究紹介］

Narukawa, M.^#, Toda, Y.^#, Nakagita, T., Hayashi, Y., and Misaka, T.*
L-Theanine elicits umami taste via the T1R1+T1R3 umami taste receptor.
Amino Acids, 46, 1583-1587, 2014.
[PubMed]

Yao, R., Yasuoka, A.*, Kamei, A., Ushiama, S., Kitagawa, Y., Rogi, T., Shibata, H., Abe, K., and Misaka, T.*
Nuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages.
PLoS ONE, 9, e87142, 2014.
[PubMed] ［研究紹介］

Nekohashi, M., Ogawa, M., Ogihara, T., Nakazawa, K., Kato, H., Misaka, T., Abe, K., and Kobayashi, S.*
Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter Niemann-Pick C1-like 1 in Caco-2 cells and rats.
PLoS ONE, 9, e97901, 2014.
[PubMed] ［研究紹介］

Toda, Y., Nakagita, T., Hayakawa, T., Okada, S., Narukawa, M., Imai, H., Ishimaru, Y., and Misaka, T.*
Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
J. Biol. Chem. 288, 36863-36877, 2013.
[PubMed] ［研究紹介］

Ieki, T., Okada, S., Aihara, Y., Ohmoto, M., Abe, K., Yasuoka, A.*, and Misaka, T.*
Transgenic labeling of higher order neuronal circuits linked to phospholipase C-beta2-expressing taste bud cells in medaka fish.
J. Comp. Neurol. 521, 1781-1802, 2013.
[PubMed] ［研究紹介］

Maeda, N., Kawakami, S., Ohmoto, M., le Coutre, J., Vinyes-Pares, G., Arigoni, F., Okada, S., Abe, K., Aizawa, H.*, and Misaka, T.*
Differential expression analysis throughout the weaning period in the mouse cerebral cortex.
Biochem. Biophys. Res. Commun. 431, 437-443, 2013.
[PubMed]

Misaka, T. (Review)
Development of a cultured cell-based human-taste evaluation system.
Biosci. Biotechnol. Biochem. 77, 1613-1616, 2013.
[PubMed]

Misaka, T. (Review)
Molecular mechanisms of the action of miraculin, a taste-modifying protein.
Semin. Cell Dev. Biol. 24, 222-225, 2013.
[PubMed]

Son, H. J., Kim, Y., Misaka, T., Noh, B. S., and Rhyu, M. R.*
Activation of the chemosensory ion channels TRPA1 and TRPV1 by hydroalcohol extract of Kalopanax pictus leaves.
Biomol. Ther. 20, 550-555, 2012.
[PubMed]

Yamazaki, T., Narukawa, M., Mochizuki, M., Misaka, T., and Watanabe, T.*
Activation of the hTAS2R14 human bitter-taste receptor by (-)-epigallocatechin gallate and (-)-epicatechin gallate.
Biosci. Biotechnol. Biochem. 77, 1981-1983, 2013.
[PubMed]

Kamei, A., Watanabe, Y., Kondo, K., Okada, S., Shinozaki, F., Ishijima, T., Nakai, Y., Kondo, T., Arai, S., and Abe, K.*
Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats.
PLoS ONE 8, e65732, 2013.
[PubMed]

Kawakami, S., Ohmoto, M., Itoh, S., Yuasa, R., Inagaki, H., Nishimura, E., Ito, T., and Misaka, T.*
Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation.
Neuroscience 218, 326-334, 2012.
[PubMed] ［研究紹介］

Okada, S., Abuyama, M., Yamamoto, R., Kondo, T., Narukawa, M., and Misaka, T.*
Dietary zinc status reversibly alters both the feeding behaviors of the rats and gene expression patterns in diencephalon.
Biofactors 38, 203-218, 2012.
[PubMed]

Ishii, S., Kurokawa, A., Kishi, M., Yamagami, K., Okada, S., Ishimaru, Y., and Misaka, T.*
The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs.
FEBS J. 279, 1857-1870, 2012.
[PubMed]

Masuda, K., Koizumi, A., Nakajima, K., Tanaka, T., Abe, K., Misaka, T.*, and Ishiguro, M.*
Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds.
PLoS ONE 7, e35380, 2012.
[PubMed] ［研究紹介］

Ishii, S., Kishi, M., Yamagami, K., Okada, S., Abe, K., and Misaka, T.*
The use of mammalian cultured cells loaded with a fluorescent dye shows specific membrane penetration of undissociated acetic acid.
Biosci. Biotechnol. Biochem. 76, 523-529, 2012.
[PubMed]

Fujiwara, S., Imada, T., Nakagita, T., Okada, S., Nammoku, T., Abe, K., and Misaka, T.*
Sweeteners interacting with the transmembrane domain of the human sweet-taste receptor induce sweet-taste synergisms in binary mixtures.
Food Chem. 130, 561-568, 2012.
[Food Chemistry]

Hata, T., Tazawa, S., Ohta, S., Rhyu, M. R., Misaka, T., and Ichihara, K.*
Artepillin C, a major ingredient of brazilian propolis, induces a pungent taste by activating TRPA1 channels.
PLoS ONE 7, e48072, 2012.
[PubMed]

Imai, H.*, Suzuki, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Abe, K., Misaka, T., and Hirai, H.
Functional diversity of bitter taste receptor TAS2R16 in primates.
Biol. Lett. 8, 652-656, 2012.
[PubMed]

Kobayashi, S.*, Katsuyama, S., Wagatsuma, T., Okada, S., and Tanabe, S.
Identification of a new IgE-binding epitope of peanut oleosin that cross-reacts with buckwheat.
Biosci. Biotechnol. Biochem. 76, 1182-1188, 2012.
[PubMed]

Ito, K.*, Hikida, A., Kitagawa, S., Misaka, T., Abe, K., and Kawarasaki, Y.
Soy peptides enhance heterologous membrane protein productivity during the exponential growth phase of Saccharomyces cerevisiae.
Biosci. Biotechnol. Biochem. 76, 628-631, 2012.
[PubMed]

Hara, K., Inada, Y., Ono, T., Kuroda, K., Yasuda-Kamatani, Y., Ishiguro, M., Tanaka, T., Misaka, T., Abe, K., and Ueda, M.*
Chimeric yeast G-protein α subunit harboring a 37-residue C-terminal gustducin-specific sequence is functional in Saccharomyces cerevisiae.
Biosci. Biotechnol. Biochem. 76, 512-516, 2012.
[PubMed]

Suyama, T., Okada, S., Ishijima, T., Iida, K., Abe, K., and Nakai, Y.*
High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis.
PLoS ONE 7, e29483, 2012.
[PubMed]

Toda, Y., Okada, S., and Misaka, T.*
Establishment of a new cell-based assay to measure the activity of sweeteners in fluorescent food extracts.
J. Agric. Food Chem. 59, 12131-12138, 2011.
[PubMed]

Koizumi, A., Tsuchiya, A., Nakajima, K., Ito, K., Terada, T., Shimizu-Ibuka, A., Briand, L., Asakura, T., Misaka, T.*, and Abe, K.*
Human sweet taste receptor mediates acid-induced sweetness of miraculin.
Proc. Natl. Acad. Sci. U.S.A. 108, 16819-16824, 2011.
[PubMed] ［研究紹介］

Yao, R., Yasuoka, A., Kamei, A., Kitagawa, Y., Rogi, T., Taieishi, N., Tsuruoka, N., Kiso, Y., Misaka, T., and Abe, K.*
Polyphenols in alcoholic beverages activating constitutive androstane receptor CAR.
Biosci. Biotechnol. Biochem. 75, 1635-1637, 2011.
[PubMed]

Nakajima, K., Koizumi, A., Iizuka, K., Ito, K., Morita, Y., Koizumi, T., Asakura, T., Shimizu-Ibuka, A., Misaka, T., and Abe, K.*
Non-acidic compounds induce the intense sweet taste of neoculin, a taste-modifying protein.
Biosci. Biotechnol. Biochem. 75, 1600-1602, 2011.
[PubMed]

Ueno, Y., Sakurai, T., Okada, S., Abe, K., and Misaka, T.*
Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.
Biosci. Biotechnol. Biochem. 75, 1188-1190, 2011.
[PubMed]

Nakajima, K., Yokoyama, K., Koizumi, T., Koizumi, A., Asakura, T., Terada, T., Masuda, K., Ito, K., Shimizu-Ibuka, A., Misaka, T., and Abe, K.*
Identification and modulation of the key amino acid residue responsible for the pH sensitivity of neoculin, a taste-modifying protein.
PLoS ONE 6, e19448, 2011.
[PubMed] ［研究紹介］

Izuchi, R.*, Nakai, Y., Takahashi, H., Ushiama, S., Okada, S., Misaka, T., and Abe, K.
Hepatic gene expression of the insulin signaling pathway is altered by administration of persimmon peel extract: a DNA microarray study using type 2 diabetic goto-kakizaki rats.
J. Agric. Food Chem. 59, 3320-3329, 2011.
[PubMed]

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Misaka, T., Iwata, S., Kobayashi, T.*, and Abe, K.*
Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.
Biotechnol. Lett. 33, 103-107, 2011.
[PubMed]

Matsumoto, I.*, Ohmoto, M., Narukawa, M., Yoshihara, Y., and Abe, K.*
Skn-1a (Pou2f3) specifies taste receptor cell lineage.
Nat. Neurosci. 14, 685-687, 2011.
[PubMed] ［研究紹介］

Nakai, Y.*, Sato, B., Ushiama, S., Okada, S., Abe, K., and Arai, S.
Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
Biosci. Biotechnol. Biochem. 75, 774-776, 2011.
[PubMed]

Ohmoto, M., Okada, S., Nakamura, S., Abe, K., and Matsumoto, I.*
Mutually exclusive expression of Galphaia and Galpha14 reveals diversification of taste receptor cells in zebrafish.
J. Comp. Neurol. 519, 1616-1629, 2011.
[PubMed]

Ito, K., Ito, S.*, Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A. D., and Iwata, S.
Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans.
J. Mol. Biol. 408, 177-186, 2011.
[PubMed]

Narukawa, M., Noga, C., Ueno, Y., Sato, T., Misaka, T., and Watanabe, T.*
Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.
Biochem. Biophys. Res. Commun. 405, 620-625, 2011.
[PubMed]

Fujimoto, C., Ishimaru, Y.*, Katano, Y., Misaka, T., Yamasoba, T., Asakura, T., and Abe, K.*
The single pore residue Asp(523) in PKD2L1 determines Ca(2+) permeation of the PKD1L3/PKD2L1 complex.
Biochem. Biophys. Res. Commun. 404, 946-951, 2011.
[PubMed]

Sakurai, T., Misaka, T.*, Ueno, Y., Ishiguro, M., Matsuo, S., Ishimaru, Y., Asakura, T., and Abe, K.
The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.
Biochem. Biophys. Res. Commun. 402, 595-601, 2010.
[PubMed]

Ito, K., Sugawara, T., Koizumi, A., Nakajima, K., Shimizu-Ibuka, A., Shiroishi, M., Asada, H., Yurugi-Kobayashi, T., Shimamura, T., Asakura, T., Masuda, K., Ishiguro, M., Misaka, T., Iwata, S., Kobayashi, T.*, and Abe, K.*
Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin.
Biochim. Biophys. Acta 1800, 986-992, 2010.
[PubMed]

Sakurai, T., Misaka, T.*, Ishiguro, M., Masuda, K., Sugawara, T., Ito, K., Kobayashi, T., Matsuo, S., Ishimaru, Y., Asakura, T., and Abe, K.
Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.
J. Biol. Chem. 285, 28373-28378, 2010.
[PubMed] ［研究紹介］

Imada, T., Misaka, T.*, Fujiwara, S., Okada, S., Fukuda, Y., and Abe, K.
Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor.
Biochem. Biophys. Res. Commun. 397, 220-225, 2010.
[PubMed]

Yao, R., Yasuoka, A., Kamei, A., Kitagawa, Y., Tateishi, N., Tsuruoka, N., Kiso, Y., Sueyoshi, T., Negishi, M., Misaka, T., and Abe, K.*
Dietary flavonoids activate the constitutive androstane receptor (CAR).
J. Agric. Food Chem. 58, 2168-2173, 2010.
[PubMed]

Iizuka, Y., Okuno, T., Saeki, K., Uozaki, H., Okada, S., Misaka, T., Sato, T., Toh, H., Fukayama, M., Takeda, N., Kita, Y., Shimizu, T., Nakamura, M.*, and Yokomizo, T.*
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.
Faseb J. 24, 4678-4690, 2010.
[PubMed]

Miyano, M., Yamashita, H., Sakurai, T., Nakajima, K., Ito, K., Misaka, T., Ishimaru, Y., Abe, K.*, and Asakura, T.*
Surface plasmon resonance analysis on interactions of food components with a taste epithelial cell model.
J. Agric. Food Chem. 58, 11870-11875, 2010.
[PubMed]

Ishimaru, Y.*, Katano, Y., Yamamoto, K., Akiba, M., Misaka, T., Roberts, R. W., Asakura, T., Matsunami, H., and Abe, K.*
Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae.
Faseb J. 24, 4058-4067, 2010.
[PubMed]

Ito, K., Ito, S.*, Shimamura, T., Kawarasaki, Y., Abe, K., Misaka, T., Kobayashi, T., and Iwata, S.
Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66, 1086-1088, 2010.
[PubMed]

Nakamura, A.*, Fujiwara, S., Ishijima, T., Okada, S., Nakai, Y., Matsumoto, I., Misaka, T., and Abe, K.
Neuron differentiation-related genes are up-regulated in the hypothalamus of odorant-inhaling rats subjected to acute restraint stress.
J. Agric. Food Chem. 58, 7922-7929, 2010.
[PubMed]

Ushiama, S., Nakamura, T., Ishijima, T., Misaka, T., Abe, K., and Nakai, Y.*
The hepatic genes for immunoproteasome are upregulated by refeeding after fasting in the rat.
Biosci. Biotechnol. Biochem. 74, 1320-1323, 2010.
[PubMed]

Masuda, K., Koizumi, A., Misaka, T., Hatanaka, Y., Abe, K., Tanaka, T., Ishiguro, M., and Hashimoto, M.*
Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives.
Bioorg. Med. Chem. Lett. 20, 1081-1083, 2010.
[PubMed]